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Papers Please! – An Abuse of Causation – “High activity enables life on a high-sugar diet: blood glucose regulation in nectar-feeding bats”

“High blood glucose levels caused by excessive sugar consumption are detrimental to mammalian health and life expectancy. Despite consuming vast quantities of sugar-rich floral nectar, nectar-feeding bats are long-lived, provoking the question of how they regulate blood glucose” (1). So goes the introductory sentences of the abstract of Kelm et al.’s High activity enables life… Read More Papers Please! – An Abuse of Causation – “High activity enables life on a high-sugar diet: blood glucose regulation in nectar-feeding bats”

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Papers Please! – “Biological Activity of Masked Endotoxin”

As written previously (A Paper a Day Keeps the Doctorate Away: Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling), research suggesting that saturated fatty acids are inflammatory via activation on toll-like receptor 4 (TLR4) has been questioned. This 2017 Nature Scientific Report expands greatly on the subject (1). The primary question: can endotoxin,… Read More Papers Please! – “Biological Activity of Masked Endotoxin”

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Proofreading Science: See What is There

Henri Poincaré famously, and correctly, admonished assistants who brought grammatical errors to his attention. Focus placed on polish tends to be at the expense of substance, a common bildungsphilister characteristic. With minds at their acme in trivia, detail polishers are largely incapable of the introspection and intuition required for discovery. That the former is selected… Read More Proofreading Science: See What is There

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Fat Stacks: The Unmitigated Success of Government Metabolic Health Research

Obesity research in America is primarily funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), an institute of the National Institutes of Health (NIH). A brief history of the institute: President Truman signed the Omnibus Medical Research Act into law on August 15, 1950, to establish the National Institute of Arthritis… Read More Fat Stacks: The Unmitigated Success of Government Metabolic Health Research

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A Paper a Day Keeps the Doctorate Away: “Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways”

Huang et al. report on a series of experiments designed to show that saturated fatty acids (SFA), lauric (C:12) and palmitic (C:16) acids specifically, activate inflammatory signaling pathways through toll-like receptors (TLRs, TLR2 & TLR4) 1. Additionally, this article is a response to an article I previously wrote about, Erridge and Samani’s “Saturated Fatty Acids… Read More A Paper a Day Keeps the Doctorate Away: “Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways”

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Dissertation Proposal – Obesity and Hypothalamic Inflammation from High Fat Diets with Different fatty Acid Profiles

As I work on my dissertation, reflecting on how few people will read it, I realize that no one will read my dissertation proposal ever again, as they are not published but only exist on the hard drives of your dissertation committee until they chose to delete it. So I am posting it here, in the… Read More Dissertation Proposal – Obesity and Hypothalamic Inflammation from High Fat Diets with Different fatty Acid Profiles

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A Paper a Day Keeps the Doctorate Away: What is Inflammation? Are We Ready to Move Beyond Celsus?

In their short leader for the British Journal of Sports Medicine, A. Scott et alia ask a question [1] that has puzzled me throughout my graduate career. I have yet to come across a satisfactory definition of inflammation, the answer sooner or later coming to rest at a point of tautology; there exists a hundred… Read More A Paper a Day Keeps the Doctorate Away: What is Inflammation? Are We Ready to Move Beyond Celsus?